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Animal models of human disease: Challenges in enabling translation

Biochemical Pharmacology · 2013 · Vol. 87(1) · pp. 162–171
Paul McGonigleBruce Ruggeri
Animal testing and alternativesComputational Drug Discovery MethodsViral Infectious Diseases and Gene Expression in InsectsContext (archaeology)DiseaseDrug developmentClinical trialAnimal modelMedicineDrug discoveryComputational modelIdentification (biology)Computer science

MeSH terms

AnimalsDisease Models, AnimalHumansAnimals, Genetically ModifiedDrug DiscoveryTranslational Research, Biomedical
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581
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Animal research: Reporting <i>in vivo</i> experiments: The ARRIVE guidelines
British Journal of Pharmacology · 2010 · 3,606 citations
Can the pharmaceutical industry reduce attrition rates?
Nature Reviews Drug Discovery · 2004 · 4,081 citations
The validity of animal models of depression
Psychopharmacology · 1984 · 1,391 citations
Believe it or not: how much can we rely on published data on potential drug targets?
Nature Reviews Drug Discovery · 2011 · 1,909 citations
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