article Open AccessTop 1% cited
Protein abundance profiling of the Escherichia coli cytosol
BMC Genomics · 2008 · Vol. 9(1) · pp. 102–102
Yasushi Ishihama✉(Keio University)Thorsten Schmidt(Technical University of Munich)Juri Rappsilber(Wellcome Centre for Cell Biology)Matthias Mann(Max Planck Institute of Biochemistry)F. Ulrich Hartl(Max Planck Institute of Biochemistry)Michael J. Kerner(Technical University of Denmark)Dmitrij Frishman(Institute of Groundwater Ecology)
Abstract
Abundance measurements for more than 1000 E. coli proteins presented in this work represent the most complete study of protein abundance in a bacterial cell so far. We show significant associations between the abundance of a protein and its properties and functions in the cell. In this way, we provide both data and novel insights into the role of protein concentration in this model organism.
Advanced Proteomics Techniques and ApplicationsGenomics and Phylogenetic StudiesMass Spectrometry Techniques and ApplicationsBiologyProteomicsRibosomal proteinProteomeEscherichia coliComputational biologyBiochemistryIsobaric labelingFractionationQuantitative proteomics
MeSH terms
Chromatography, LiquidCytosolEscherichia coliMass SpectrometryEscherichia coli ProteinsProteomics
Funding
- European Commission
- Deutsche Forschungsgemeinschaft
- Keio University
- Eisai
Citations
482
FWCI
16.93
field-weighted impact
References
74
Percentile
100%
vs. same field & year
Citations per year
Cited by
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PLoS Computational Biology · 2010 · 700 citations
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