article Open AccessTop 1% cited
Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway
Cell Metabolism · 2013 · Vol. 18(5) · pp. 649–659
Christiane D. Wrann(Harvard University)James P. White(Dana-Farber Cancer Institute)John Salogiannnis(Harvard University)Dina Laznik-Bogoslavski(Dana-Farber Cancer Institute)Jun Wu(Dana-Farber Cancer Institute)Di Ma(University of Michigan–Ann Arbor)Jiandie D. Lin(University of Michigan–Ann Arbor)Michael E. Greenberg✉(Harvard University)Bruce M. Spiegelman✉(Dana-Farber Cancer Institute)
Adipose Tissue and MetabolismPeroxisome Proliferator-Activated ReceptorsMitochondrial Function and PathologyFNDC5Neurotrophic factorsGene knockdownHippocampal formationNeuroprotectionEndocrinologyInternal medicineHippocampusBrain-derived neurotrophic factorCiliary neurotrophic factor
MeSH terms
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaERRalpha Estrogen-Related ReceptorAdenoviridaeAnimalsFibronectinsGenetic VectorsHippocampusHumansMaleMice, Inbred C57BLNeuronsPhysical Conditioning, AnimalProtein BindingReceptors, EstrogenRecombinant Proteins
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References
FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
Metabolism · 2012 · 1,024 citations
Fitness Effects on the Cognitive Function of Older Adults
Psychological Science · 2003 · 3,727 citations
Neurotrophin regulation of neural circuit development and function
Nature reviews. Neuroscience · 2012 · 1,950 citations
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
European Journal of Neuroscience · 2004 · 1,426 citations
Exercise builds brain health: key roles of growth factor cascades and inflammation
Trends in Neurosciences · 2007 · 2,207 citations
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