article Open AccessTop 1% cited
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0
Nature Protocols · 2011 · Vol. 6(9) · pp. 1290–1307
Jan Schellenberger✉(University of California, San Diego)Richard Que(University of California, San Diego)Ronan M. T. Fleming(University of Iceland)Ines Thiele(University of Iceland)Jeffrey D. Orth(University of California, San Diego)Adam M. Feist(University of California, San Diego)Daniel C. Zielinski(University of California, San Diego)Aarash Bordbar(La Jolla Bioengineering Institute)Nathan E. Lewis(La Jolla Bioengineering Institute)Sorena Rahmanian(University of California, San Diego)Joseph Kang(La Jolla Bioengineering Institute)Daniel R. Hyduke(University of California, San Diego)Bernhard Ø. Palsson(University of California, San Diego)
Microbial Metabolic Engineering and BioproductionBioinformatics and Genomic NetworksGene Regulatory Network AnalysisToolboxComputer scienceCobraSBMLIn silicoSystems biologyScripting languageMarkup languageComputational biologyUsability
MeSH terms
AlgorithmsSoftwareComputational BiologyMetabolic Networks and Pathways
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References
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A protocol for generating a high-quality genome-scale metabolic reconstruction
Nature Protocols · 2010 · 1,850 citations
An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
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The KEGG resource for deciphering the genome
Nucleic Acids Research · 2003 · 5,208 citations
Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110
Applied and Environmental Microbiology · 1994 · 1,080 citations
KEGG: Kyoto Encyclopedia of Genes and Genomes
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