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Expanding GSK's solvent selection guide – embedding sustainability into solvent selection starting at medicinal chemistry

Green Chemistry · 2011 · Vol. 13(4) · pp. 854–854

Richard K. Henderson✉Concepción Jiménez‐González(Research Triangle Park Foundation)David J. C. Constable(Lockheed Martin (United States))Sarah R. Alston(Research Triangle Park Foundation)Graham G. A. Inglis(Age UK)Gail Fisher(Age UK)James Sherwood(Universities UK)Steve P. BinksAlan D. Curzons

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Abstract

Solvents make a large contribution to the environmental impact of manufacturing processes of active pharmaceutical ingredients (API), as well as playing an important role in other chemical industries, with millions of tons used and disposed of each year. GlaxoSmithKline (GSK) has previously reported on the both the development of a GSK solvent selection guide and the incorporation of solvent life cycle inventory and assessment information. The GSK solvent selection guide has been further enhanced by:

Chemistry and Chemical Engineering Process Optimization and Integration Various Chemistry Research TopicsSolventSelection (genetic algorithm)Life cycle inventorySustainabilityChemistryBiochemical engineeringLife-cycle assessmentOrganic chemistryComputer scienceEngineering

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