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Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia
Archives of General Psychiatry · 2000 · Vol. 57(1) · pp. 65–65
Leisa A. Glantz✉(University of Pittsburgh)David A. Lewis
Abstract
This region- and disease-specific decrease in dendritic spine density on dorsolateral prefrontal cortex layer 3 pyramidal cells is consistent with the hypothesis that the number of cortical and/or thalamic excitatory inputs to these neurons is altered in subjects with schizophrenia.
Neuroscience and Neuropharmacology ResearchFunctional Brain Connectivity StudiesNeural dynamics and brain functionDendritic spinePrefrontal cortexNeuroscienceDorsolateral prefrontal cortexSchizophrenia (object-oriented programming)PsychologyExcitatory postsynaptic potentialCortex (anatomy)Inhibitory postsynaptic potentialPsychiatry
MeSH terms
AdolescentAdultAgedAutopsyCognition DisordersDendritesColoring AgentsFemaleHumansMaleMemory DisordersMiddle AgedNeural PathwaysSchizophreniaThalamus
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