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Reduced dendritic spine density on cerebral cortical pyramidal neurons in schizophrenia

Journal of Neurology Neurosurgery & Psychiatry · 1998 · Vol. 65(4) · pp. 446–453

L.J. Garey✉(Charing Cross Hospital)Wei‐Yi Ong(National University of Singapore)Tejesh Patel(National University of Singapore)Mazyar Kanani(National University of Singapore)Adam Davis(National University of Singapore)Ann Mortimer(National University of Singapore)ThomasRE Barnes(National University of Singapore)S.R. Hirsch(National University of Singapore)

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Abstract

The results support the concept of there being a defect in the fine structure of dendrites of pyramidal neurons, involving loss of spines, in schizophrenia and may help to explain the loss of cortical volume without loss of neurons in this condition, although the effect of neuroleptic drugs cannot be ruled out.

Schizophrenia research and treatment Functional Brain Connectivity Studies Neuroscience and Neuropharmacology ResearchNeocortexDendritic spineSchizophrenia (object-oriented programming)Cerebral cortexPsychosisPsychologyCortex (anatomy)Temporal cortexNeuroscienceMedicine

MeSH terms

AdultAgedAged, 80 and overAlzheimer DiseaseCell CountCerebral CortexDendritesFemaleHumansMaleMiddle AgedNeuronsProspective StudiesSchizophreniaSpinal Nerves