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The outcome of surgery in 668 patients with acromegaly using current criteria of biochemical ‘cure’

European Journal of Endocrinology · 2005 · Vol. 152(3) · pp. 379–387

P. Nomikos✉(Friedrich-Alexander-Universität Erlangen-Nürnberg)Michael Buchfelder(Friedrich-Alexander-Universität Erlangen-Nürnberg)Rudolf Fahlbusch(Friedrich-Alexander-Universität Erlangen-Nürnberg)

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Abstract

These data suggest that surgery remains with very few exceptions the primary treatment of acromegaly for (i) a high cure rate, (ii) low morbidity, (iii) low recurrence rate and (iv) immediate decline of GH. Based on current criteria of cure, recurrences are uncommon. However, cure by surgery alone is improbable in patients harbouring extended, invasive tumours with high secretory activity, in whom further adjuvant treatment is mandatory.

Pituitary Gland Disorders and Treatments Growth Hormone and Insulin-like Growth Factors TGF-β signaling in diseasesAcromegalyMedicineCure rateTranssphenoidal surgerySurgeryBasal (medicine)ComplicationMortality rateInternal medicineAdenoma

MeSH terms

IncidenceTreatment OutcomeRemission InductionReoperationAcromegalyAdenomaAdministration, OralAdolescentAdultAgedFemaleFollow-Up StudiesGlucoseHumansInsulin-Like Growth Factor I

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502

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11.26

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99%

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Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry