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RegPrecise 3.0 – A resource for genome-scale exploration of transcriptional regulation in bacteria

BMC Genomics · 2013 · Vol. 14(1) · pp. 745–745
Pavel S. NovichkovAlexey E. KazakovDmitry A. RavcheevSemen A. LeynGalina Yu KovalevaRoman A. SutorminMarat D. KazanovWilliam J. RiehlAdam P. ArkinInna DubchakDmitry A. Rodionov

Abstract

RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in bacterial genomes. Analytical capabilities include exploration of: regulon content, structure and function; TF binding site motifs; conservation and variations in genome-wide regulatory networks across all taxonomic groups of Bacteria. RegPrecise 3.0 was selected as a core resource on transcriptional regulation of the Department of Energy Systems Biology Knowledgebase, an emerging software and data environment designed to enable researchers to collaboratively generate, test and share new hypotheses about gene and protein functions, perform large-scale analyses, and model interactions in microbes, plants, and their communities.

RNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesBacterial Genetics and BiotechnologyRegulonBiologyComparative genomicsGenomeComputational biologyGeneticsBacterial genome sizeGenomicsGeneRegulation of gene expression

MeSH terms

BacteriaTranscription FactorsUser-Computer InterfaceGenome, BacterialInternetDatabases, GeneticGene Regulatory NetworksMetabolic Networks and Pathways

Funding

  • U.S. Department of Energy
  • Russian Foundation for Basic Research
  • Biological and Environmental Research
  • Lawrence Berkeley National Laboratory
  • Pacific Northwest National Laboratory
Citations
474
FWCI
12.26
field-weighted impact
References
44
Percentile
99%
vs. same field & year
Citations per year
References
The Pfam Protein Families Database
Nucleic Acids Research · 2002 · 14,220 citations
The COG database: an updated version includes eukaryotes
BMC Bioinformatics · 2003 · 4,484 citations
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