article Open AccessTop 1% cited
Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
Gut · 1997 · Vol. 40(3) · pp. 297–301
Julie Parsonnet✉(Stanford University)G D Friedman(Stanford University)Norman Orentreich∥(Stanford University)H Vogelman(Stanford University)
Abstract
When compared with uninfected subjects, persons infected with CagA positive H pylori are at considerably increased risk of gastric cancer. CagA negative H pylori are less strongly linked to malignancy and may only be associated with diffuse type disease.
Helicobacter pylori-related gastroenterology studiesGalectins and Cancer BiologyGastrointestinal disorders and treatmentsCagAHelicobacter pyloriOdds ratioCancerMedicineGastroenterologyAntibodyInternal medicineSpirillaceaeImmunology
MeSH terms
ABO Blood-Group SystemAgedAntibodies, BacterialAntigens, BacterialBacterial ProteinsEducational StatusFemaleHumansImmunoglobulin GMaleMiddle AgedPepsinogensPhenotypeRegression AnalysisRisk Factors
Funding
- National Institutes of Health
- National Cancer Institute
Citations
965
FWCI
52.12
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
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References
Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin
Infection and Immunity · 1995 · 593 citations
Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection.
Gut · 1997 · 965 citations
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