Meta‐analysis: the effect of antibiotic resistance status on the efficacy of triple and quadruple first‐line therapies for <i>Helicobacter pylori</i>

Abstract

Drug resistance was a strong predictor of efficacy across triple therapies for the eradication of H. pylori in adults. Resistance to either clarithromycin or metronidazole, but not both simultaneously, may be overcome by using quadruple therapies, especially those containing both clarithromycin and metronidazole.