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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

The EMBO Journal · 2008 · Vol. 27(2) · pp. 433–446

Gilad Twig✉(Tufts University)Álvaro A. Elorza(Tufts University)Anthony Molina(Tufts University)Hibo Mohamed(Tufts University)Jakob D. Wikström(Tufts University)Gil Walzer(Tufts University)Linsey Stiles(Tufts University)Sarah E. Haigh(Tufts University)Steve Katz(Tufts University)Guy Las(Tufts University)Joseph Alroy(Tufts University)Min Wu(ProterixBio (United States))Bénédicte F. Py(Harvard University)Junying Yuan(Harvard University)Jude T. Deeney(Boston University)Barbara E. Corkey(Boston University)Orian S. Shirihai(Tufts University)

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Mitochondrial Function and Pathology Autophagy in Disease and Therapy Endoplasmic Reticulum Stress and DiseaseMitochondrial fissionFIS1AutophagyMitochondrionBiologymitochondrial fusionCell biologyMFN2MitophagyLipid bilayer fusion

MeSH terms

Autophagy-Related Protein 5Insulin SecretionAnimalsAutophagyCell LineGenotypeInsulinMaleMice, Inbred C57BLMicrotubule-Associated ProteinsMitochondriaModels, BiologicalMutationReactive Oxygen SpeciesMicroscopy, Confocal

Funding

National Science Foundation
National Institutes of Health

Citations

3,057

FWCI

51.58

field-weighted impact

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100%

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References

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Journal of Clinical Investigation · 2005 · 1,662 citations

Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

The Journal of Cell Biology · 2005 · 2,311 citations

Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells

American Journal of Physiology-Cell Physiology · 2006 · 919 citations

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

Diabetes · 2000 · 932 citations

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