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Statins Upregulate <i>PCSK9</i> , the Gene Encoding the Proprotein Convertase Neural Apoptosis-Regulated Convertase-1 Implicated in Familial Hypercholesterolemia

Arteriosclerosis Thrombosis and Vascular Biology · 2004 · Vol. 24(8) · pp. 1454–1459

Geneviève Dubuc✉(Montreal Clinical Research Institute)Ann Chamberland(Montreal Clinical Research Institute)Hanny Wassef(Montreal Clinical Research Institute)Jean Davignon(Montreal Clinical Research Institute)Nabil G. Seidah(Montreal Clinical Research Institute)Lise Bernier(Montreal Clinical Research Institute)Annik Prat(Montreal Clinical Research Institute)

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Abstract

PCSK9 regulation is typical of that of the genes implicated in lipoprotein metabolism. In vivo, PCSK9 is probably a target of SRE-binding protein (SREBP)-2.

Cholesterol and Lipid Metabolism Lipoproteins and Cardiovascular Health Hormonal Regulation and HypertensionPCSK9LDL receptorProprotein convertaseBiologySterol regulatory element-binding proteinDownregulation and upregulationApolipoprotein BCell biologyLipoproteinGene

MeSH terms

AtorvastatinProprotein Convertase 9Liver X ReceptorsAlitretinoinAnimalsBase SequenceCell LineCholesterolDNA-Binding ProteinsGene Expression RegulationHeptanoic AcidsHomeostasisHumansHydroxycholesterolsHydroxymethylglutaryl CoA Reductases

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The C679X mutation in PCSK9 is present and lowers blood cholesterol in a Southern African population