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Somatic mutations in the<i>PTCH</i>,<i>SMOH</i>,<i>SUFUH</i>and<i>TP53</i>genes in sporadic basal cell carcinomas
British Journal of Dermatology · 2005 · Vol. 152(1) · pp. 43–51
J. Reifenberger✉(Heinrich Heine University Düsseldorf)Marietta Wolter(Heinrich Heine University Düsseldorf)Christiane B. Knobbe‐Thomsen(Heinrich Heine University Düsseldorf)Benjamin Köhler(Heinrich Heine University Düsseldorf)Alexandra Schönicke(Heinrich Heine University Düsseldorf)C. Scharwächter(Heinrich Heine University Düsseldorf)Krishan Kumar(Heinrich Heine University Düsseldorf)Britta Blaschke(Heinrich Heine University Düsseldorf)Thomas Ruzicka(Heinrich Heine University Düsseldorf)G. Reifenberger(Heinrich Heine University Düsseldorf)
Abstract
Our data confirm the importance of PTCH, SMOH and TP53 mutations in the pathogenesis of sporadic BCCs. SUFUH alterations are restricted to individual cases while the other investigated genes do not appear to be important targets for mutations in BCCs.
Hedgehog Signaling Pathway StudiesCancer and Skin LesionsNonmelanoma Skin Cancer StudiesHRASGLI1Neuroblastoma RAS viral oncogene homologBiologyKRASLoss of heterozygosityCancer researchMissense mutationBasal cell carcinomaMutation
MeSH terms
Patched ReceptorsPatched-1 ReceptorSmoothened ReceptorAdultAgedAged, 80 and overBase SequenceBasal Cell CarcinomaCarcinoma, Basal CellDNA Mutational AnalysisDNA, NeoplasmFemaleHumansMaleMembrane Proteins
Funding
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
Citations
396
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References
The epidemiology of skin cancer
British Journal of Dermatology · 2002 · 1,100 citations
Mutations of the BRAF gene in human cancer
Nature · 2002 · 10,619 citations
Molecular cloning: A laboratory manual
Analytical Biochemistry · 1990 · 86,156 citations
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