article Open AccessTop 1% cited
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1
The EMBO Journal · 2004 · Vol. 23(4) · pp. 833–843
José M. Lizcano✉(MRC Protein Phosphorylation and Ubiquitylation Unit)Olga Göransson(University of Dundee)Rachel Toth(MRC Protein Phosphorylation and Ubiquitylation Unit)Mária Deák(University of Dundee)Nick Morrice(MRC Protein Phosphorylation and Ubiquitylation Unit)Jérôme Boudeau(University of Dundee)Simon A. Hawley(University of Dundee)Lina Udd(University of Helsinki)Tomi P. Mäkelä(Helsinki University Hospital)D. Grahame Hardie(University of Dundee)Dario R. Alessi(University of Dundee)
Metabolism, Diabetes, and CancerPlant nutrient uptake and metabolismFOXO transcription factor regulationSubfamilyKinaseAMPKCell biologyProtein-Serine-Threonine KinasesBiologyProtein kinase AGeneticsGene
MeSH terms
AMP-Activated Protein Kinase KinasesAmino Acid SequenceCell LineEnzyme ActivationFibroblastsHumansMolecular Sequence DataMultienzyme ComplexesMutationPeptidesPhosphorylationProtein BindingSubstrate SpecificityProtein Serine-Threonine KinasesProtein Subunits
Funding
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- University of Dundee
- Merck KGaA
- Wellcome Trust
- Diabetes UK
- European Commission
- Medical Research Council
Citations
1,359
FWCI
23.90
field-weighted impact
References
57
Percentile
100%
vs. same field & year
Citations per year
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References
Management of cellular energy by the AMP‐activated protein kinase system
FEBS Letters · 2003 · 855 citations
LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade
Current Biology · 2003 · 1,631 citations
The Protein Kinase Complement of the Human Genome
Science · 2002 · 8,071 citations
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
European Journal of Biochemistry · 1995 · 1,182 citations
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
European Journal of Biochemistry · 1995 · 909 citations
Role of AMP-activated protein kinase in mechanism of metformin action
Journal of Clinical Investigation · 2001 · 5,364 citations
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