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Role of the Toll-like Receptor 4/NF-κB Pathway in Saturated Fatty Acid–Induced Inflammatory Changes in the Interaction Between Adipocytes and Macrophages

Arteriosclerosis Thrombosis and Vascular Biology · 2006 · Vol. 27(1) · pp. 84–91

Takayoshi Suganami✉(The University of Tokyo)Kanami Tanimoto-Koyama(The University of Tokyo)Junko Nishida(Tokyo Medical and Dental University)Michiko Itoh(Tokyo Medical and Dental University)Xunmei Yuan(Tokyo Medical and Dental University)Shinji Mizuarai(Tokyo Medical and Dental University)Hidehito Kotani(The University of Tokyo)Shoji Yamaoka(The University of Tokyo)Kensuke Miyake(Tokyo Medical and Dental University)Seiichiro Aoe(Tokyo Medical and Dental University)Yasutomi Kamei(The University of Tokyo)Yoshihiro Ogawa(The University of Tokyo)

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Abstract

These findings suggest that saturated FAs, which are released in large quantities from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for TLR4, thereby inducing the inflammatory changes in both adipocytes and macrophages through NF-kappaB activation.

Adipokines, Inflammation, and Metabolic Diseases Fatty Acid Research and Health Adipose Tissue and MetabolismAdipocyteProinflammatory cytokineLipolysisTLR4Internal medicineTumor necrosis factor alphaAdipose tissueEndocrinologyInflammationChemistry

MeSH terms

AnimalsCell CommunicationCell LineFatty AcidsFatty Acids, NonesterifiedGene Expression RegulationHypertrophyInflammationLipolysisMacrophagesMice, Mutant StrainsObesityTumor Necrosis Factor-alphaSignal TransductionNF-kappa B

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