article Open AccessTop 1% cited
A Paracrine Loop Between Adipocytes and Macrophages Aggravates Inflammatory Changes
Arteriosclerosis Thrombosis and Vascular Biology · 2005 · Vol. 25(10) · pp. 2062–2068
Takayoshi Suganami✉(Tokyo Medical and Dental University)Junko Nishida(Tokyo Medical and Dental University)Yoshihiro Ogawa(Tokyo Medical and Dental University)
Abstract
We postulate that a paracrine loop involving FFAs and TNF-alpha between adipocytes and macrophages establishes a vicious cycle that aggravates inflammatory changes in the adipose tissue.
Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismExercise and Physiological ResponsesAdipose tissue macrophagesAdipose tissueInflammationProinflammatory cytokineTumor necrosis factor alphaParacrine signallingAdipocyteEndocrinologyInternal medicineDownregulation and upregulation
MeSH terms
Adipose TissueAnimalsCell CommunicationFatty Acids, NonesterifiedGene Expression RegulationHypertrophyInflammationMacrophagesObesityTumor Necrosis Factor-alphaAdipocytesCoculture TechniquesChemokine CCL2Paracrine CommunicationMetabolic Syndrome
Funding
- Japan Research Foundation for Clinical Pharmacology
- Ministry of Education, Culture, Sports, Science and Technology
- Novo Nordisk
- Smoking Research Foundation
- Kanae Foundation for the Promotion of Medical Science
- Mishima Kaiun Memorial Foundation
Citations
1,023
FWCI
25.26
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
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References
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.
Journal of Clinical Investigation · 1995 · 3,504 citations
Minireview: Adiposity, Inflammation, and Atherogenesis
Endocrinology · 2003 · 756 citations
‘Green mice’ as a source of ubiquitous green cells
FEBS Letters · 1997 · 2,599 citations
Obesity is associated with macrophage accumulation in adipose tissue
Journal of Clinical Investigation · 2003 · 8,580 citations
Prevalence of the Metabolic Syndrome Among US Adults
JAMA · 2002 · 6,709 citations
Handbook of Physiology.
Archives of Neurology · 1960 · 10,386 citations
Absence of Monocyte Chemoattractant Protein-1 Reduces Atherosclerosis in Low Density Lipoprotein Receptor–Deficient Mice
Molecular Cell · 1998 · 1,564 citations
Definition of Metabolic Syndrome
Circulation · 2004 · 5,942 citations
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