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Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

Clinical Cancer Research · 2005 · Vol. 11(2) · pp. 728–734

Sandra Demaria✉(New York University)Noriko Kawashima(New York University)Anne Marie Yang(New York University)M. Devitt(New York University)James S. Babb(New York University)James P. Allison(Memorial Sloan Kettering Cancer Center)Silvia C. Formenti(Molecular Oncology (United States))

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Abstract

The combination of local RT with CTLA-4 blockade is a promising new immunotherapeutic strategy against poorly immunogenic metastatic cancers.

Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses Immune Cell Function and InteractionMedicineBlockadePrimary tumorCD8ImmunotherapyImmune systemCancerBreast cancerCancer researchAntibody

MeSH terms

AnimalsAntibodies, MonoclonalAntigens, DifferentiationCobalt RadioisotopesCombined Modality TherapyDisease Models, AnimalFemaleImmunoglobulin Fc FragmentsImmunosuppressive AgentsLung NeoplasmsMammary Neoplasms, ExperimentalMice, Inbred BALB CRadiotherapy DosageAntigens, CDSurvival Rate

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Cited by

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody