article Open AccessTop 10% cited
Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody
Clinical Cancer Research · 2009 · Vol. 15(17) · pp. 5379–5388
Md. Zahidunnabi Dewan(NYU Langone Health)Ashley E. Galloway(NYU Langone Health)Noriko Kawashima(NYU Langone Health)J. Keith DeWyngaert(NYU Langone Health)James S. Babb(NYU Langone Health)Silvia C. Formenti(NYU Langone Health)Sandra Demaria✉(NYU Langone Health)
Abstract
Fractionated but not single-dose radiotherapy induces an abscopal effect when in combination with anti-CTLA-4 antibody in two preclinical carcinoma models.
Cancer Immunotherapy and BiomarkersCancer, Stress, Anesthesia, and Immune ResponseImmunotherapy and Immune ResponsesAbscopal effectRadiation therapyMedicineCD8Cancer researchAntibodyImmunotherapyGrowth inhibitionNasopharyngeal carcinomaCarcinoma
MeSH terms
AnimalsAntibodies, MonoclonalCarcinomaColonic NeoplasmsCombined Modality TherapyInterferon-gammaMammary Neoplasms, ExperimentalMice, Inbred BALB CMice, Inbred C57BLRadiotherapy DosageAntigens, CDCD8-Positive T-LymphocytesDose Fractionation, RadiationCell Line, TumorMice
Funding
- U.S. Department of Defense
- Breast Cancer Research Foundation
- Chemotherapy Foundation
- York University
- National Institutes of Health
Citations
1,622
FWCI
8.56
field-weighted impact
References
32
Percentile
98%
vs. same field & year
Citations per year
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References
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated
International Journal of Radiation Oncology*Biology*Physics · 2004 · 1,349 citations
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Nature Medicine · 2007 · 2,933 citations
Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer
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