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Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

Cell Metabolism · 2013 · Vol. 17(2) · pp. 225–235
Sama I. SayinAnnika WahlströmJenny FelinSirkku JänttiHanns–Ulrich MarschallKrister BambergBo AngelinTuulia HyötyläinenMatej OrešičFredrik Bäckhed
Drug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsEpigenetics and DNA MethylationBile acidFarnesoid X receptorEnterohepatic circulationCholesterol 7 alpha-hydroxylaseCholic acidIleumGut floraG protein-coupled bile acid receptorBiologyInternal medicine

MeSH terms

AbsorptionReceptor, Farnesoid X-ActivatedAnimalsAnti-Bacterial AgentsBile Acids and SaltsCholesterol 7-alpha-HydroxylaseFibroblast Growth FactorsGene Expression RegulationIleumLiverModels, BiologicalOrgan SpecificityTaurocholic AcidReceptors, Cytoplasmic and NuclearGene Expression Profiling

Funding

  • Göteborgs Universitet
Citations
2,204
FWCI
56.17
field-weighted impact
References
39
Percentile
100%
vs. same field & year
Citations per year
References
Bile salt biotransformations by human intestinal bacteria
Journal of Lipid Research · 2005 · 2,751 citations
Bile acids: regulation of synthesis
Journal of Lipid Research · 2009 · 1,598 citations
The Enzymes, Regulation, and Genetics of Bile Acid Synthesis
Annual Review of Biochemistry · 2003 · 2,001 citations
Bile acid transporters
Journal of Lipid Research · 2009 · 656 citations
Bile acids as regulatory molecules
Journal of Lipid Research · 2009 · 684 citations
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Bile acids: regulation of synthesis
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