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Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

The Lancet Neurology · 2008 · Vol. 7(7) · pp. 583–590

Daniel G. Healy✉(National Hospital for Neurology and Neurosurgery)Mario Falchi(Imperial College London)Sean S. O’Sullivan(University of London)Vincenzo Bonifati(Erasmus MC)Alexandra Durr(Inserm)Susan Bressman(Albert Einstein College of Medicine)Alexis Brice(Inserm)Jan Aasly(Norwegian University of Science and Technology)Cyrus P. Zabetian(University of Washington)Stefano Goldwurm(Istituti Clinici di Perfezionamento)Joaquim J. Ferreira(Institute of Molecular Medicine)Eduardo Tolosa(Universitat de Barcelona)Denise M. Kay(New York State Department of Health)Christine Klein(University of Lübeck)David R. Williams(Monash University)Connie Marras(University of Toronto)Anthony E. Lang(University of Toronto)Zbigniew K. Wszołek(Jacksonville College)José Berciano(Marqués de Valdecilla University Hospital)Anthony H.V. Schapira(University College London)Timothy Lynch(Mater Misericordiae University Hospital)Kailash P. Bhatia(Sobell House)Thomas Gasser(University of Tübingen)Andrew J. Lees(University of London)Nicholas Wood(National Hospital for Neurology and Neurosurgery)

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Abstract

UK Medical Research Council; UK Parkinson's Disease Society; UK Brain Research Trust; Internationaal Parkinson Fonds; Volkswagen Foundation; National Institutes of Health: National Institute of Neurological Disorders and Stroke and National Institute of Aging; Udall Parkinson's Disease Centre of Excellence; Pacific Alzheimer Research Foundation Centre; Italian Telethon Foundation; Fondazione Grigioni per il Morbo di Parkinson; Michael J Fox Foundation for Parkinson's Research; Safra Global Genetics Consortium; US Department of Veterans Affairs; French Agence Nationale de la Recherche.

Parkinson's Disease Mechanisms and Treatments Banana Cultivation and Research Lysosomal Storage Disorders ResearchLRRK2PenetranceDiseaseDyskinesiaMutationMedicineGenotypeParkinson's diseaseInternal medicineMutation frequency

MeSH terms

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2Age FactorsDNA Mutational AnalysisFamily HealthFemaleGenetic TestingGenotypeGlycineHumansInternational CooperationMaleParkinson DiseaseRiskSerineSeverity of Illness Index