Evaluation of Three Mushroom Species Ethanol Extracts in the Treatment of Postrate Cancer in Wister Albino Rats and Phytochemical Analysis of the Fungi in Nigeria

Abstract

This study was aimed at evaluating the phytochemistry and anti-postrate cancer activities of three mushroom species in adult male wistar rats. The crude extracts of Ganoderma lucidum, Pleurotus porrigens and Pleurotus pulmonarius was used in the treatment of postrate cancer in wistar albino rat. A significant reduction in the postrate specific antigen of the induced group with 0.21±0.1ng/ml compared to the other control groups. There were significant increase in the haemoglobin content with 31.80±1.6, white blood cell 5.30±0.9 and mole corpuscular volume 69.70±0.5FL in the treated group compared to the control. Furthermore, significant reductions in the stimulating hormones (GSH) superoxide dismutate (SOD) and increases in catalase (CAT) were observed in the treated postrate cancer animal compared to the control groups. Reduction in creatinine and increase in chlorine (Cl) and potassium level was observed in the treated group compared with control group. The result showed that the phytomedicine had a good antipostrate cancer activity and the result of phytochemical screening revealed the presence of medicinally important constituent in the fungi.