article Open AccessTop 1% cited
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides
BMC Bioinformatics · 2007 · Vol. 8(1) · pp. 65–65
Oscar Conchillo‐Solé✉(Universitat Autònoma de Barcelona)Natalia Sánchez de Groot(Universitat Autònoma de Barcelona)Francesc Avilés(Universitat Autònoma de Barcelona)Josep Vendrell(Universitat Autònoma de Barcelona)Xavier Daura(Universitat Autònoma de Barcelona)Salvador Ventura(Universitat Autònoma de Barcelona)
Abstract
By identifying aggregation-prone segments in proteins, AGGRESCAN http://bioinf.uab.es/aggrescan/ shall facilitate (i) the identification of possible therapeutic targets for anti-depositional strategies in conformational diseases and (ii) the anticipation of aggregation phenomena during storage or recombinant production of bioactive polypeptides or polypeptide sets.
Alzheimer's disease research and treatmentsProtein Structure and DynamicsProteins in Food SystemsProtein aggregationComputational biologyBiologyAnticipation (artificial intelligence)Protein foldingHuman proteinsChemistryBiochemistryGeneComputer science
MeSH terms
HumansPeptidesPredictive Value of TestsProtein ConformationProteinsSoftwareDrug Delivery Systems
Funding
- Generalitat de Catalunya
Citations
1,067
FWCI
13.35
field-weighted impact
References
98
Percentile
99%
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Citations per year
Cited by
Immunogenicity of Therapeutic Protein Aggregates
Journal of Pharmaceutical Sciences · 2016 · 510 citations
References
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
Biochemistry · 1993 · 1,996 citations
Protein Misfolding, Functional Amyloid, and Human Disease
Annual Review of Biochemistry · 2006 · 6,373 citations
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