articleTop 1% cited
Cerebrospinal Fluid tau/β-Amyloid42 Ratio as a Prediction of Cognitive Decline in Nondemented Older Adults
Archives of Neurology · 2007 · Vol. 64(3) · pp. 343–343
Anne M. Fagan✉(Washington University in St. Louis)Catherine M. RoeChengjie XiongMark A. MintunJohn C. MorrisDavid M. Holtzman
Abstract
The very mildest symptomatic stage of AD exhibits the same CSF biomarker phenotype as more advanced AD. In addition, levels of CSF Abeta(42), when combined with amyloid imaging, augment clinical methods for identifying in individuals with brain amyloid deposits whether dementia is present or not. Importantly, CSF tau/Abeta(42) ratios show strong promise as antecedent (preclinical) biomarkers that predict future dementia in cognitively normal older adults.
Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNeurological Disease Mechanisms and TreatmentsClinical Dementia RatingCerebrospinal fluidHazard ratioDementiaInternal medicineBiomarkerPittsburgh compound BConfidence intervalMedicineCognitive decline
MeSH terms
AgedAged, 80 and overAgingCognition DisordersDementiaFemaleHumansMaleMiddle AgedPeptide FragmentsPredictive Value of TestsChi-Square DistributionAmyloid beta-Peptidestau Proteins
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