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Meta-analyses involving cross-over trials: methodological issues

International Journal of Epidemiology · 2002 · Vol. 31(1) · pp. 140–149
Diana R ElbourneDouglas G. AltmanJulian P. T. HigginsFrançois CurtinHelen V WorthingtonAndy Vail

Abstract

Methods do exist for including valuable information from two-period, two-treatment cross-over trials into quantitative reviews. However, poor reporting of cross-over trials will often impede attempts to perform a meta-analysis using the available methods.

Meta-analysis and systematic reviewsMeta-analysisRandomized controlled trialContext (archaeology)Clinical trialMedicineCochrane LibraryMEDLINEMedical physicsSystematic reviewCross over

MeSH terms

HumansReview Literature as TopicMeta-Analysis as TopicRandomized Controlled Trials as TopicCross-Over Studies

Funding

  • Medical Research Council
Citations
2,281
FWCI
46.45
field-weighted impact
References
37
Percentile
100%
vs. same field & year
Citations per year
References
Variance imputation for overviews of clinical trials with continuous response
Journal of Clinical Epidemiology · 1992 · 1,355 citations
The two‐period cross‐over clinical trial.
British Journal of Clinical Pharmacology · 1979 · 1,399 citations
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