review Open AccessTop 1% cited
Plasmid-Determined AmpC-Type β-Lactamases
Antimicrobial Agents and Chemotherapy · 2002 · Vol. 46(1) · pp. 1–11
A. Philippon✉(Hôpital Cochin)Guillaume Arlet(Hôpital Tenon)George A. Jacoby(Lahey Hospital and Medical Center)
Abstract
The predominant mechanism for resistance to β-lactam antibiotics in gram-negative bacteria is the synthesis of β-lactamase. To meet this challenge, β-lactams with greater β-lactamase stability, including cephalosporins, carbapenems, and monobactams, were introduced in the 1980s. Resistance
Antibiotic Resistance in BacteriaPharmaceutical and Antibiotic Environmental ImpactsAntibiotics Pharmacokinetics and EfficacyCephalosporinMicrobiologyAntibioticsPlasmidLactamGram-negative bacteriaBacteriaEnterobacteriaceaeBiologyChemistry
MeSH terms
Anti-Bacterial AgentsBacteriaBacterial Proteinsbeta-LactamasesDrug ResistanceMicrobial Sensitivity TestsMolecular Sequence DataPlasmidsbeta-Lactamase Inhibitors
Citations
799
FWCI
15.04
field-weighted impact
References
94
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References
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Antimicrobial Agents and Chemotherapy · 1995 · 2,450 citations
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