article Open AccessTop 1% cited
Anti-inflammatory properties of the short-chain fatty acids acetate and propionate: A study with relevance to inflammatory bowel disease
World Journal of Gastroenterology · 2007 · Vol. 13(20) · pp. 2826–2826
Sofia TedelindFredrik Westberg(AstraZeneca (Sweden))Martin Kjerrulf(AstraZeneca (Sweden))Alexander Vidal✉(AstraZeneca (Sweden))
Abstract
In the present study propionate and butyrate were equipotent, whereas acetate was less effective, at suppressing NF-kappaB reporter activity, immune-related gene expression and cytokine release in vitro. Our findings suggest that propionate and acetate, in addition to butyrate, could be useful in the treatment of inflammatory disorders, including IBD.
Helicobacter pylori-related gastroenterology studiesNF-κB Signaling PathwaysImmune Response and InflammationButyratePropionateCytokineChemistryProinflammatory cytokinePharmacologyInternal medicineMolecular biologyInflammationEndocrinology
MeSH terms
AcetatesAdenocarcinomaAnimalsAnti-Inflammatory AgentsButyratesColonic NeoplasmsDose-Response Relationship, DrugFemaleGene Expression RegulationHumansMice, Inbred C57BLNeutrophilsPropionatesTumor Necrosis Factor-alphaInflammatory Bowel Diseases
Citations
839
FWCI
14.28
field-weighted impact
References
43
Percentile
99%
vs. same field & year
Citations per year
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References
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The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Journal of Biological Chemistry · 2003 · 2,311 citations
Review article: short chain fatty acids in health and disease
Alimentary Pharmacology & Therapeutics · 1998 · 622 citations
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Gut · 2000 · 1,308 citations
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