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Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
Diabetologia · 2011 · Vol. 54(10) · pp. 2506–2514
Ee Lin Lim✉(Newcastle University)Kieren G. Hollingsworth(Newcastle University)Benjamin S. Aribisala(Newcastle University)Melinda Chen(Newcastle University)John C. Mathers(Newcastle University)Roy Taylor(Newcastle University)
Abstract
Normalisation of both beta cell function and hepatic insulin sensitivity in type 2 diabetes was achieved by dietary energy restriction alone. This was associated with decreased pancreatic and liver triacylglycerol stores. The abnormalities underlying type 2 diabetes are reversible by reducing dietary energy intake.
Pancreatic function and diabetesMetabolism, Diabetes, and CancerDiet and metabolism studiesInternal medicineEndocrinologyInsulinInsulin resistanceDiabetes mellitusBasal (medicine)MedicineType 2 diabetesBeta cellPancreas
MeSH terms
AdultAgedBlood GlucoseBody CompositionBody WeightDiabetes Mellitus, Type 2FemaleGlycated HemoglobinHumansLiverMaleMiddle AgedPancreasTriglyceridesInsulin-Secreting Cells
Citations
1,142
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61.60
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52
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American Journal of Physiology-Endocrinology and Metabolism · 2004 · 1,562 citations
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