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The Mechanism of Diabetes Control After Gastrointestinal Bypass Surgery Reveals a Role of the Proximal Small Intestine in the Pathophysiology of Type 2 Diabetes

Annals of Surgery · 2006 · Vol. 244(5) · pp. 741–749

Francesco Rubino✉(Institut de Recherche contre les Cancers de l’Appareil Digestif)Antonello Forgione✉(Université de Strasbourg)David E. Cummings(University of Washington)Michel Vix✉(Université de Strasbourg)Donatella Gnuli(Università Cattolica del Sacro Cuore)Geltrude Mingrone(Università Cattolica del Sacro Cuore)M Castagneto(Università Cattolica del Sacro Cuore)Jacques Marescaux✉(Université de Strasbourg)

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Abstract

This study shows that bypassing a short segment of proximal intestine directly ameliorates type 2 diabetes, independently of effects on food intake, body weight, malabsorption, or nutrient delivery to the hindgut. These findings suggest that a proximal intestinal bypass could be considered for diabetes treatment and that potentially undiscovered factors from the proximal bowel might contribute to the pathophysiology of type 2 diabetes.

Bariatric Surgery and Outcomes Diet and metabolism studies Diabetes Treatment and ManagementMedicineSmall intestineDiabetes mellitusInternal medicineStomachGlucose homeostasisType 2 diabetesEndocrinologyPathophysiologyWeight loss

MeSH terms

AnimalsBlood GlucoseDiabetes Mellitus, Type 2Disease Models, AnimalFatty Acids, NonesterifiedGlucose Tolerance TestInsulinIntestinal AbsorptionIntestine, SmallMaleObesity, MorbidPostoperative PeriodGastric BypassWeight GainTreatment Outcome