articleTop 1% cited

B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients

Lara D. Veeken · 2005 · Vol. 44(12) · pp. 1542–1545

Maria Leandro✉(University College London)Geraldine Cambridge(University College London)Jonathan Edwards(University College London)Michael R. Ehrenstein(University College London)David Isenberg(University College London)

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Abstract

In this open study of patients who had failed conventional immunosuppressive therapy, considerable utility in the use of B-cell depletion has been demonstrated. Our data provide strong support for the performance of a full double-blind control trial.

Systemic Lupus Erythematosus Research T-cell and B-cell Immunology Monoclonal and Polyclonal Antibodies ResearchMedicineAzathioprineRituximabMethylprednisoloneImmunosuppressionGastroenterologyInternal medicineCyclophosphamideSystemic lupus erythematosusConcomitant

MeSH terms

RituximabAdolescentAdultAntibodies, MonoclonalAntibodies, AntinuclearComplement C3FemaleFollow-Up StudiesHumansImmunosuppressive AgentsLupus Erythematosus, SystemicLymphocyte DepletionMaleSeverity of Illness IndexB-Lymphocyte Subsets

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The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults