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Moving pictures of the human microbiome

Genome biology · 2011 · Vol. 12(5) · pp. R50–R50
J. Gregory CaporasoChristian L. LauberElizabeth K. CostelloDonna Berg-LyonsAntonio GonzálezJesse StombaughDan KnightsPawel GajerJacques RavelNoah FiererJeffrey I. GordonRob Knight

Abstract

DNA sequencing and computational advances described here provide the ability to go beyond infrequent snapshots of our human-associated microbial ecology to high-resolution assessments of temporal variations over protracted periods, within and between body habitats and individuals. This capacity will allow us to define normal variation and pathologic states, and assess responses to therapeutic interventions.

Gut microbiota and healthClostridium difficile and Clostridium perfringens researchBiologyHuman geneticsMicrobiomeGenome BiologyComputational biologyHuman microbiomeEvolutionary biologyHuman genomeData scienceGenomics

MeSH terms

BacteriaComputer SimulationHumansObesityOrgan SpecificityRNA, Ribosomal, 16SSeasonsTime FactorsInflammatory Bowel DiseasesGenomicsGastrointestinal TractMetagenomeHigh-Throughput Nucleotide Sequencing

Funding

  • Howard Hughes Medical Institute
  • Bill and Melinda Gates Foundation
  • Crohn's and Colitis Foundation of America
  • Amazon Web Services
  • Crohn's and Colitis Foundation
  • National Institutes of Health
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Moving pictures of the human microbiome · Scinovex