article Open AccessTop 1% cited
Moving pictures of the human microbiome
Genome biology · 2011 · Vol. 12(5) · pp. R50–R50
J. Gregory Caporaso✉(University of Colorado Boulder)Christian L. Lauber(University of Colorado Boulder)Elizabeth K. Costello(Stanford University)Donna Berg-Lyons(Cooperative Institute for Research in Environmental Sciences)Antonio González(University of Colorado Boulder)Jesse Stombaugh(University of Colorado Boulder)Dan Knights(University of Colorado Boulder)Pawel Gajer(University of Maryland, Baltimore)Jacques Ravel(University of Maryland, Baltimore)Noah Fierer(University of Colorado Boulder)Jeffrey I. Gordon(Washington University in St. Louis)Rob Knight(Howard Hughes Medical Institute)
Abstract
DNA sequencing and computational advances described here provide the ability to go beyond infrequent snapshots of our human-associated microbial ecology to high-resolution assessments of temporal variations over protracted periods, within and between body habitats and individuals. This capacity will allow us to define normal variation and pathologic states, and assess responses to therapeutic interventions.
Gut microbiota and healthClostridium difficile and Clostridium perfringens researchBiologyHuman geneticsMicrobiomeGenome BiologyComputational biologyHuman microbiomeEvolutionary biologyHuman genomeData scienceGenomics
MeSH terms
BacteriaComputer SimulationHumansObesityOrgan SpecificityRNA, Ribosomal, 16SSeasonsTime FactorsInflammatory Bowel DiseasesGenomicsGastrointestinal TractMetagenomeHigh-Throughput Nucleotide Sequencing
Funding
- Howard Hughes Medical Institute
- Bill and Melinda Gates Foundation
- Crohn's and Colitis Foundation of America
- Amazon Web Services
- Crohn's and Colitis Foundation
- National Institutes of Health
Citations
1,166
FWCI
32.21
field-weighted impact
References
21
Percentile
100%
vs. same field & year
Citations per year
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References
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PLoS Biology · 2008 · 2,333 citations
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Applied and Environmental Microbiology · 2006 · 11,173 citations
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The ISME Journal · 2009 · 1,118 citations
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PLoS Biology · 2007 · 2,829 citations
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample
Proceedings of the National Academy of Sciences · 2010 · 9,826 citations
Search and clustering orders of magnitude faster than BLAST
Bioinformatics · 2010 · 21,473 citations
A human gut microbial gene catalogue established by metagenomic sequencing
Nature · 2010 · 11,497 citations
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Science Translational Medicine · 2009 · 3,073 citations
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