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Experimental Dry Eye Stimulates Production of Inflammatory Cytokines and MMP-9 and Activates MAPK Signaling Pathways on the Ocular Surface

Investigative Ophthalmology & Visual Science · 2004 · Vol. 45(12) · pp. 4293–4293

Lihui Luo✉(Ocular Surface Center)De‐Quan Li(Ocular Surface Center)Amish Doshi(Baylor College of Medicine)William J. Farley(Ocular Surface Center)Rosa M. Corrales(Baylor College of Medicine)Stephen C. Pflugfelder(Baylor College of Medicine)

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Abstract

Experimental dry eye stimulates expression and production of IL-1beta, TNF-alpha, and MMP-9 and activates MAPK signaling pathways on the ocular surface. MAPKs are known to stimulate the production of inflammatory cytokines and MMPs, and they could play an important role in the induction of these factors that have been implicated in the pathogenesis of dry eye disease.

Ocular Surface and Contact Lens Corneal Surgery and Treatments Advanced Glycation End Products researchMAPK/ERK pathwayKinaseZymographyMolecular biologyWestern blotConjunctivap38 mitogen-activated protein kinasesMatrix metalloproteinaseChemistryInflammation

MeSH terms

AnimalsConjunctivaEnzyme-Linked Immunosorbent AssayEpitheliumEyeInterleukin-1Mice, Inbred StrainsOsmolar ConcentrationRNA, MessengerTearsTime FactorsTumor Necrosis Factor-alphaDry Eye SyndromesCytokinesInflammation Mediators

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Cited by

The International Workshop on Meibomian Gland Dysfunction: Report of the Diagnosis Subcommittee