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Production and Activity of Matrix Metalloproteinase-9 on the Ocular Surface Increase in Dysfunctional Tear Syndrome

Investigative Ophthalmology & Visual Science · 2009 · Vol. 50(7) · pp. 3203–3203

Suksri Chotikavanich✉(Mahidol University)Cintia S. de Paiva(Baylor College of Medicine)De Quan Li(Ocular Surface Center)Joseph J. Chen(Ocular Surface Center)Fang Bian(Union Hospital)William J. Farley(Ocular Surface Center)Stephen C. Pflugfelder(Baylor College of Medicine)

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Abstract

Tear MMP-9 activity was significantly higher in patients with DTS. This activity was associated with increased mRNA expression of MMP-9 and its regulating genes and correlated strongly with clinical parameters. MMP-9 appears to be a potentially useful biomarker for diagnosing, classifying, and monitoring DTS.

Ocular Surface and Contact Lens Glaucoma and retinal disorders Corneal Surgery and TreatmentsMedicineOphthalmologyMatrix metalloproteinaseMatrix Metalloproteinase 3FluoresceinInternal medicineGastroenterologyPathology

MeSH terms

AdultConjunctivaEpithelial CellsFemaleHumansMaleRNA, MessengerTearsTumor Necrosis Factor-alphaVisual AcuityDry Eye SyndromesFluorophotometryInterleukin-6Gene Expression Regulation, EnzymologicMicroscopy, Confocal

Citations

385

FWCI

16.36

field-weighted impact

References

Percentile

99%

vs. same field & year

Citations per year

Cited by

Dry Eye Disease