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A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

Neuroscience · 2002 · Vol. 112(4) · pp. 803–814
Raffaella MolteniR. J. BarnardZhe YingChristian K. RobertsFernando Gómez‐Pinilla
Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsRegulation of Appetite and ObesitySynapsin ICREBNeurotrophic factorsBrain-derived neurotrophic factorSynaptic plasticityNeurotransmitterNeurotrophinHippocampusNeuroscienceEndocrinology

MeSH terms

AnimalsCerebral CortexDietary FatsFemaleHippocampusImmunohistochemistryLearningNeuronal PlasticityRats, Inbred F344RNA, MessengerSynapsinsCyclic AMP Response Element-Binding ProteinBrain-Derived Neurotrophic FactorDietary SucroseGAP-43 Protein
Citations
908
FWCI
3.00
field-weighted impact
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51
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92%
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References
GAP-43: an intrinsic determinant of neuronal development and plasticity
Trends in Neurosciences · 1997 · 1,327 citations
Neurotrophins as synaptic modulators
Nature reviews. Neuroscience · 2001 · 1,776 citations
CREB AND MEMORY
Annual Review of Neuroscience · 1998 · 1,455 citations
Learning Deficit in BDNF Mutant Mice
European Journal of Neuroscience · 1997 · 468 citations
NEUROTROPHINS AND SYNAPTIC PLASTICITY
Annual Review of Neuroscience · 1999 · 1,332 citations
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A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning · Scinovex