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Assessment of Liver Function in Patients With Hepatocellular Carcinoma: A New Evidence-Based Approach—The ALBI Grade

Journal of Clinical Oncology · 2014 · Vol. 33(6) · pp. 550–558

Philip J. Johnson✉(Newcastle upon Tyne Hospitals NHS Foundation Trust)Sarah Berhane(Newcastle upon Tyne Hospitals NHS Foundation Trust)Chiaki Kagebayashi(Newcastle upon Tyne Hospitals NHS Foundation Trust)Shinji Satomura(Newcastle upon Tyne Hospitals NHS Foundation Trust)Mabel Teng(Newcastle upon Tyne Hospitals NHS Foundation Trust)Helen L. Reeves(Newcastle upon Tyne Hospitals NHS Foundation Trust)James O’Beirne(Newcastle upon Tyne Hospitals NHS Foundation Trust)Richard Fox(Newcastle upon Tyne Hospitals NHS Foundation Trust)Anna Skowrońska(Newcastle upon Tyne Hospitals NHS Foundation Trust)Daniel H. Palmer(Newcastle upon Tyne Hospitals NHS Foundation Trust)Winnie Yeo(Newcastle upon Tyne Hospitals NHS Foundation Trust)Frankie Mo(Newcastle upon Tyne Hospitals NHS Foundation Trust)Paul B.S. Lai(Newcastle upon Tyne Hospitals NHS Foundation Trust)Mercedes Iñarrairaegui(Newcastle upon Tyne Hospitals NHS Foundation Trust)Stephen L. Chan(Newcastle upon Tyne Hospitals NHS Foundation Trust)Bruno Sangro(Newcastle upon Tyne Hospitals NHS Foundation Trust)Rebecca A. Miksad(Newcastle upon Tyne Hospitals NHS Foundation Trust)Toshifumi Tada(Newcastle upon Tyne Hospitals NHS Foundation Trust)Takashi Kumada(Newcastle upon Tyne Hospitals NHS Foundation Trust)Hidenori Toyoda(Newcastle upon Tyne Hospitals NHS Foundation Trust)

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Abstract

The ALBI grade offers a simple, evidence-based, objective, and discriminatory method of assessing liver function in HCC that has been extensively tested in an international setting. This new model eliminates the need for subjective variables such as ascites and encephalopathy, a requirement in the conventional C-P grade.

Liver Disease Diagnosis and Treatment Liver Disease and Transplantation Hepatocellular Carcinoma Treatment and PrognosisMedicineHepatocellular carcinomaSorafenibInternal medicineGastroenterologyLiver functionLiver diseaseChronic liver diseaseBilirubinLiver function tests

MeSH terms

AgedBilirubinFemaleCarcinoma, HepatocellularHumansLiverLiver NeoplasmsMaleMiddle AgedModels, BiologicalNeoplasm StagingSerum AlbuminCohort StudiesNeoplasm Grading