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Randomised clinical trial: faecal microbiota transplantation by colonoscopy vs. vancomycin for the treatment of recurrent <i>Clostridium difficile</i> infection

Alimentary Pharmacology & Therapeutics · 2015 · Vol. 41(9) · pp. 835–843

Giovanni Cammarota✉(Catholic University of America)Luca Masucci(Catholic University of America)Gianluca Ianiro(Catholic University of America)Stefano Bibbò(Catholic University of America)Giorgia Dinoi(Catholic University of America)Guido Costamagna(Catholic University of America)Maurizio Sanguinetti(Catholic University of America)Antonio Gasbarrini(Catholic University of America)

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Abstract

Faecal microbiota transplantation using colonoscopy to infuse faeces was significantly more effective than vancomycin regimen for the treatment of recurrent C. difficile infection. The delivery of donor faeces via colonoscopy has the potential to optimise the treatment strategy in patients with pseudomembranous colitis.

Clostridium difficile and Clostridium perfringens research Microscopic Colitis Helicobacter pylori-related gastroenterology studiesClostridium difficileMedicinePseudomembranous colitisColonoscopyVancomycinRegimenInternal medicineGastroenterologyColitisTransplantation

MeSH terms

AdultAgedAged, 80 and overClostridium InfectionsColonoscopyDiarrheaEnterocolitis, PseudomembranousFecesFemaleHumansMaleMiddle AgedVancomycinClostridioides difficileTreatment Outcome

Citations

549

FWCI

38.64

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Systematic review with meta‐analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory <i>Clostridium difficile</i> infection