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Comprehensive Genomic Analysis Identifies Novel Subtypes and Targets of Triple-Negative Breast Cancer

Clinical Cancer Research · 2014 · Vol. 21(7) · pp. 1688–1698

Matthew D. Burstein(Texas Medical Center)Anna Tsimelzon(Children's Cancer Center)Graham M. Poage(The University of Texas MD Anderson Cancer Center)Kyle R. Covington(Children's Cancer Center)Alejandro Contreras(Baylor College of Medicine)Suzanne A.W. Fuqua(Children's Cancer Center)Michelle I. Savage(The University of Texas MD Anderson Cancer Center)C. Kent Osborne(Children's Cancer Center)Susan G. Hilsenbeck(Children's Cancer Center)Jenny C. Chang(Houston Methodist)Gordon B. Mills(The University of Texas MD Anderson Cancer Center)Ching C. Lau✉(Children's Cancer Center)Powel H. Brown✉(The University of Texas MD Anderson Cancer Center)

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Abstract

There are four stable TNBC subtypes characterized by the expression of distinct molecular profiles that have distinct prognoses. These studies identify novel subtype-specific targets that can be targeted in the future for the effective treatment of TNBCs.

Cancer Genomics and Diagnostics Breast Cancer Treatment Studies Cancer Cells and MetastasisTriple-negative breast cancerBreast cancerCancer researchBiologyAndrogen receptorCancerOncologyMedicineProstate cancerGenetics

MeSH terms

AdultAgedFemaleHumansMiddle AgedProportional Hazards ModelsGene Expression ProfilingKaplan-Meier EstimateTranscriptomeTriple Negative Breast Neoplasms

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