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Paraneoplastic anti– <i>N</i> ‐methyl‐ <scp>D</scp> ‐aspartate receptor encephalitis associated with ovarian teratoma

Annals of Neurology · 2007 · Vol. 61(1) · pp. 25–36

Josep Dalmau✉(University of Pennsylvania)Erdem Tüzün(University of Pennsylvania)Haiyan Wu(University of Pennsylvania)Jaime Masjuan(Hospital Universitario Ramón y Cajal)Jeffrey Rossi(University of Pennsylvania)Alfredo Voloschin(Augusta University)Joachim M. Baehring(Yale University)Haruo Shimazaki(Jichi Medical University)Reiji Koide(Tokyo Metropolitan Neurological Hospital)Dale King(Children's Hospital of Pittsburgh)Warren Mason(Princess Margaret Cancer Centre)Lauren Sansing(University of Pennsylvania)Marc A. Dichter(University of Pennsylvania)Myrna R. Rosenfeld(University of Pennsylvania)David R. Lynch(University of Pennsylvania)

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Abstract

Antibodies to NR2B- and NR2A-containing heteromers of the NMDAR associate with a severe but treatment-responsive encephalitis. Our findings provide a diagnostic test and suggest a model of autoimmune NMDAR-related encephalitis with broad implications for other immune-mediated disorders of memory, behavior, and cognition.

Autoimmune Neurological Disorders and Treatments Neuroscience and Neuropharmacology Research RNA regulation and diseaseForebrainTeratomaHippocampusPathologyEncephalitisNMDA receptorOvarian TeratomaAutoimmune encephalitisBiologyCerebrospinal fluid

MeSH terms

AdolescentAdultAnimalsAntibodiesDissectionEncephalitisFemaleHumansImmunohistochemistryImmunosuppressive AgentsMagnetic Resonance ImagingMaleNeuronsOvarian NeoplasmsTeratoma

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