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The longer term outcome of children born to mothers with epilepsy
Journal of Neurology Neurosurgery & Psychiatry · 2004 · Vol. 75(11) · pp. 1575–1583
Naghme Adab✉(University of Liverpool)
Abstract
This study identifies valproate as a drug carrying potential risks for developmental delay and cognitive impairment and is the first to suggest that frequent tonic-clonic seizures have a similar effect. Our results need to be interpreted with caution given their retrospective nature. Women with epilepsy need careful counselling about individual risk benefit of AED treatment before pregnancy.
Pharmacological Effects and Toxicity StudiesEpilepsy research and treatmentPregnancy and Medication ImpactEpilepsyCarbamazepinePediatricsIntelligence quotientWechsler Adult Intelligence ScaleMedicineRetrospective cohort studyPregnancyConfoundingPsychiatry
MeSH terms
PregnancyAbnormalities, Drug-InducedAdolescentAnticonvulsantsChildDevelopmental DisabilitiesChild, PreschoolCognition DisordersDrug Therapy, CombinationEnglandEpilepsyFemaleFollow-Up StudiesHumansInfant
Citations
580
FWCI
40.86
field-weighted impact
References
64
Percentile
100%
vs. same field & year
Citations per year
References
A clinical study of 57 children with fetal anticonvulsant syndromes
Journal of Medical Genetics · 2000 · 569 citations
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The longer term outcome of children born to mothers with epilepsy
Journal of Neurology Neurosurgery & Psychiatry · 2004 · 580 citations
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