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Chemical Constituents of Prangos tschimganica; Structure Elucidation and Absolute Configuration of Coumarin and Furanocoumarin Derivatives with Anti-HIV Activity.

Chemical and Pharmaceutical Bulletin · 2001 · Vol. 49(7) · pp. 877–880

Yasuhiro Shikishima✉(Tokushima University)Yoshihisa Takaishi(Tokushima University)Gisho Honda(Tokushima University)Michiho Ito(Kyoto Pharmaceutical University)Yoshio Takeda(Tokushima University)Olim K. Khojimatov(Tokushima University)Ozodbek Ashurmetov(Academy of Sciences Republic of Uzbekistan)Kuo‐Hsing Lee

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Abstract

The methanol extract of the dried aerial parts of Prangos tschimganica gave three new coumarin derivatives and 30 known coumarin derivatives. Their structures were established on the basis of chemical and spectroscopic evidence. Absolute configuration of the isolated compounds were determined by using a modified Mosher's method. Some of the isolated compounds showed anti-HIV activity.

Plant chemical constituents analysis Synthesis of Organic Compounds Natural product bioactivities and synthesisChemistryCoumarinFuranocoumarinAbsolute configurationStereochemistryChemical structureMethanolOrganic chemistry

MeSH terms

AcetylationCoumarinsMolecular ConformationMagnetic Resonance SpectroscopyPlants, MedicinalFurocoumarinsUzbekistanZidovudineHIV-1Spectrometry, Mass, Fast Atom BombardmentAnti-HIV AgentsApiaceae

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177

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5.26

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