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Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents

Bioorganic & Medicinal Chemistry Letters · 2005 · Vol. 15(7) · pp. 1793–1797

Chelliah Selvam✉(National Institute of Pharmaceutical Education and Research)Sanjay M. Jachak(National Institute of Pharmaceutical Education and Research)Ramasamy Thilagavathi(National Institute of Pharmaceutical Education and Research)Asit K. Chakraborti(National Institute of Pharmaceutical Education and Research)

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Curcumin's Biomedical Applications Synthesis and biological activity Natural product bioactivities and synthesisCurcuminChemistryIsoxazoleAntioxidantTroloxCurcumaDocking (animal)Anti-inflammatoryCyclooxygenasePharmacology

MeSH terms

AnimalsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsBinding SitesCurcuminMembrane ProteinsProstaglandin-Endoperoxide SynthasesStructure-Activity RelationshipCyclooxygenase InhibitorsRatsCyclooxygenase 1Cyclooxygenase 2Cyclooxygenase 2 Inhibitors

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304

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4.43

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