articleTop 10% cited
LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition
Chemical Communications · 1998 · pp. 455–456
Sanjay K. Singh✉Alexei A. KoshkinJesper Wengel(University of Copenhagen)Poul Nielsen(University of Copenhagen)
Abstract
A novel class of nucleic acid analogues, termed LNA (locked nucleic acids), is introduced. Following the Watson–Crick base pairing rules, LNA forms duplexes with complementary DNA and RNA with remarkably increased thermal stabilities and generally improved selectivities.
DNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesBacteriophages and microbial interactionsNucleic acidNucleic acid analogueLocked nucleic acidDNAChemistryRNANucleic acid structureBase pairNucleic acid methodsCombinatorial chemistry
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LNA (locked nucleic acids): synthesis and high-affinity nucleic acid recognition
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