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In Vivo Imaging of Human Cone Photoreceptor Inner Segments

Investigative Ophthalmology & Visual Science · 2014 · Vol. 55(7) · pp. 4244–4244

Drew Scoles(University of Rochester)Yusufu N. Sulai(University of Rochester)Christopher S. Langlo(Medical College of Wisconsin)Gerald A. Fishman(University of Illinois Urbana-Champaign)Christine A. Curcio(University of Alabama at Birmingham)Joseph Carroll(Medical College of Wisconsin)Alfredo Dubra✉(Medical College of Wisconsin)

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Abstract

The application of nonconfocal split-detector to emerging human gene therapy trials will improve the potential of therapeutic success, by identifying patients with sufficient retained photoreceptor structure to benefit the most from intervention. Additionally, split-detector imaging may be useful for studies of other retinal degenerations such as AMD, retinitis pigmentosa, and choroideremia where the outer segment is lost before the remainder of the photoreceptor cell.

Retinal Development and Disorders Retinal Diseases and Treatments Ophthalmology and Visual Impairment StudiesAchromatopsiaRetinaRetinitis pigmentosaRetinalScanning laser ophthalmoscopyStargardt diseasePhotoreceptor cellElectroretinographyOphthalmoscopyBiology

MeSH terms

AdultAgedAged, 80 and overColor Vision DefectsFemaleGenetic TestingHumansMaleOphthalmoscopyRetinal DegenerationRetinitis PigmentosaReproducibility of ResultsTomography, Optical CoherenceRetinal Photoreceptor Cell Inner Segment