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Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis

BMJ · 2012 · Vol. 344(may17 1) · pp. e3054–e3054

Katharine Ker✉(University of London)Phil Edwards(University of London)Pablo Perel(University of London)H. Shakur(University of London)Ian Roberts(University of London)

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Abstract

Strong evidence that tranexamic acid reduces blood transfusion in surgery has been available for many years. Further trials on the effect of tranexamic acid on blood transfusion are unlikely to add useful new information. However, the effect of tranexamic acid on thromboembolic events and mortality remains uncertain. Surgical patients should be made aware of this evidence so that they can make an informed choice.

Blood transfusion and management Trauma, Hemostasis, Coagulopathy, Resuscitation Blood groups and transfusionTranexamic acidMedicinePulmonary embolismDeep veinThrombosisMeta-analysisMyocardial infarctionPlaceboStroke (engine)Randomized controlled trial

MeSH terms

Antifibrinolytic AgentsBlood TransfusionHumansMyocardial InfarctionThromboembolismTranexamic AcidRandomized Controlled Trials as TopicBlood Loss, SurgicalStroke