review Open Access
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
Cochrane Database of Systematic Reviews · 2011 · pp. CD001886–CD001886
David Henry✉Paul A Carless(University of Newcastle Australia)Annette Moxey(University of Newcastle Australia)Dianne L. O’ConnellBarrie Stokes(University of Newcastle Australia)Dean A Fergusson(University of Ottawa)Katharine Ker(London School of Hygiene & Tropical Medicine)
Abstract
Anti-fibrinolytic drugs provide worthwhile reductions in blood loss and the receipt of allogeneic red cell transfusion. Aprotinin appears to be slightly more effective than the lysine analogues in reducing blood loss and the receipt of blood transfusion. However, head to head comparisons show a lower risk of death with lysine analogues when compared with aprotinin. The lysine analogues are effective in reducing blood loss during and after surgery, and appear to be free of serious adverse effects.
Blood transfusion and managementTrauma, Hemostasis, Coagulopathy, ResuscitationCardiac and Coronary Surgery TechniquesMedicineAprotininBlood managementPerioperativeIntensive care medicineBlood lossBlood transfusionSurgery
MeSH terms
AdultAntifibrinolytic AgentsHumansAprotininTranexamic AcidTransplantation, HomologousAminocaproic AcidRandomized Controlled Trials as TopicBlood Loss, SurgicalErythrocyte Transfusion
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References
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion
Cochrane Database of Systematic Reviews · 2011 · 1,069 citations
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Journal of Thoracic and Cardiovascular Surgery · 1989 · 539 citations
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JAMA · 1995 · 5,518 citations
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