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Seizure‐Promoting Effect of Blood–Brain Barrier Disruption

Epilepsia · 2007 · Vol. 48(4) · pp. 732–742

Nicola Marchi✉(Neurological Surgery)Lilyana Angelov(Neurological Surgery)T. MasarykVincent Fazio(Neurological Surgery)Tiziana Granata(Fondazione IRCCS Istituto Neurologico Carlo Besta)Nadia HernandezKerri Hallene(Neurological Surgery)Tammy Diglaw(Neurological Surgery)Linda Franic(Neurology, Inc)Imad Najm(Neurology, Inc)Damir Janigro(Neurological Surgery)

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Abstract

This is the first study to correlate extent of acute BBB openings and development of seizures in humans and in a large animal model of BBB opening. Acute vascular failure is sufficient to cause seizures in the absence of CNS pathologies or chemotherapy.

Traumatic Brain Injury and Neurovascular Disturbances Neuroscience and Neuropharmacology Research S100 Proteins and AnnexinsBlood–brain barrierNeuroscienceEpilepsyMedicinePsychologyCentral nervous system

MeSH terms

AdultAnimalsAntineoplastic AgentsBlood-Brain BarrierBrainBrain NeoplasmsCerebrovascular DisordersDisease Models, AnimalElectroencephalographyFemaleHumansInfusions, Intra-ArterialFunctional LateralityLymphomaMale

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492

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