reviewTop 1% cited

Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means

Neurosurgery · 1998 · Vol. 42(5) · pp. 1083–1099

Robert A. KrolI✉(Oregon Health & Science University)Edward A. Neuwelt(Oregon Health & Science University)Edward A. Neuwelt(Oregon Health & Science University)

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Abstract

Improving delivery of agents to the brain will play a major role in the therapeutic outcome of brain neoplasms. As techniques for gene therapy are advanced, manipulation of the BBB also may be important in the treatment of central nervous system genetic disorders.

Glioma Diagnosis and Treatment Neuroblastoma Research and Treatments Brain Metastases and TreatmentMedicineBlood–brain barrierBradykininNeuroscienceCentral nervous systemBioinformaticsIntensive care medicinePharmacologyInternal medicineBiology

MeSH terms

AnimalsImmunotoxinsAntineoplastic AgentsBlood-Brain BarrierBradykininBrain NeoplasmsCognition DisordersDogsForecastingHumansHypertonic SolutionsMannitolOsmotic PressureParkinson DiseasePharmacokinetics

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