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Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates

Journal of Pharmacology and Experimental Therapeutics · 2001 · Vol. 296(2) · pp. 235–242

James E. Dunford✉(University of Aberdeen)Keith ThompsonFraser P. CoxonSteven P. Luckman(University of Aberdeen)Frederick M. Hahn(University of Hawaiʻi at Mānoa)C. Dale PoulterFrank H. Ebetino(Procter & Gamble (Netherlands))Michael J. Rogers

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Bone health and treatments Radiopharmaceutical Chemistry and Applications Bone Metabolism and DiseasesFarnesyl diphosphate synthasePotencyIn vivoBone resorptionChemistryPrenylationPharmacologyIn vitroBiochemistryATP synthase

MeSH terms

AnimalsBone ResorptionDiphosphonatesEnzyme InhibitorsIndicators and ReagentsMevalonic AcidOsteoclastsProtein ConformationRabbitsRecombinant ProteinsStructure-Activity RelationshipProtein PrenylationNitrogen CompoundsAlkyl and Aryl TransferasesGeranyltranstransferase

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894

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12.34

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Biochemical and molecular mechanisms of action of bisphosphonates