reviewTop 1% cited
Biochemical and molecular mechanisms of action of bisphosphonates
Bone · 2010 · Vol. 49(1) · pp. 34–41
Michael J. Rogers✉(University of Aberdeen)Julie C. Crockett(University of Aberdeen)Fraser P. Coxon(University of Aberdeen)Jukka Mönkkönen(University of Eastern Finland)
Bone health and treatmentsBone Metabolism and DiseasesBone and Joint DiseasesOsteoclastMevalonate pathwayBisphosphonateBone resorptionPrenylationChemistryFarnesyl pyrophosphateFarnesyl diphosphate synthaseDiphosphonatesBiochemistry
MeSH terms
AnimalsBone and BonesDimethylallyltranstransferaseDiphosphonatesHumansProtein PrenylationIntracellular SpaceMetabolic Networks and Pathways
Citations
513
FWCI
12.72
field-weighted impact
References
103
Percentile
99%
vs. same field & year
Citations per year
Cited by
Bisphosphonates: The first 40years
Bone · 2011 · 1,093 citations
References
Mitochondrial control of cell death
Nature Medicine · 2000 · 3,102 citations
Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
Journal of Bone and Mineral Research · 1998 · 1,185 citations
Structure-Activity Relationships for Inhibition of Farnesyl Diphosphate Synthase in Vitro and Inhibition of Bone Resorption in Vivo by Nitrogen-Containing Bisphosphonates
Journal of Pharmacology and Experimental Therapeutics · 2001 · 894 citations
Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo
Journal of Bone and Mineral Research · 1995 · 1,044 citations
PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences
Annual Review of Biochemistry · 1996 · 2,008 citations
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Nitrogen-Containing Bisphosphonates Inhibit the Mevalonate Pathway and Prevent Post-Translational Prenylation of GTP-Binding Proteins, Including Ras
Journal of Bone and Mineral Research · 1998 · 1,185 citations
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