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DNA TOPOISOMERASE POISONS AS ANTITUMOR DRUGS

Annual Review of Biochemistry · 1989 · Vol. 58(1) · pp. 351–375
Leroy F. Liu

Abstract

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

Biotechnology and Related FieldsHippo pathway signaling and YAP/TAZDrosophila melanogasterRegulatorBiologyCell biologyTopoisomeraseDNAHippo signaling pathwayCell fate determinationCell growthComputational biology

MeSH terms

AnimalsAnti-Infective AgentsAntineoplastic AgentsDNA, NeoplasmDrug ResistanceHumansMammals4-QuinolonesTopoisomerase I Inhibitors
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